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Home News Science Autologous Fibroblast Injection

Autologous Fibroblast Injection

Autologous Fibroblast Injections are a derma regeneration mechanism being superior to commonly-used methods such as PRP or mesotherapy, and also helps achieve long-term results without the need for third-party substances and repeated manipulations associated with Botox and hyaluronic acid injections. This rejuvenation is based on the introduction of people’s own cells (fibroblasts); through it, cells naturally-removed over time are replaced and skin-aging is resisted.

What does fibroblast therapy engage?

  1. Biopsy. Dermatologists grab a 3mm-thick-sample of skin from a non-irradiated area in the clinic. The skin sample is immediately placed in a special medium (provided by a dedicated clinical or laboratory facility) before being transferred to laboratory for cell cultivation.
  2. Cultivation. Fibroblasts are grown from a skin explant under optimal conditions. After 4-6 weeks of cell growth, they are collected and prepared to be sent back to the clinic in a special environment.
  3. Injection procedure. Dermatologists inject a specifically-aimed injection medium optimized for fibroblasts into the skin in the clinic. If necessary, this injection can be repeated.

Fibroblasts can be stored in a laboratory or clinical setting for many years for future injections or wound healing with AFT if required. Cells grown in the laboratory can be kept in a special cryogenic storage facility. This makes it possible to use them in the future. They are stored in liquid nitrogen at -196°C and can remain there without damage for an unlimited period. At any time they can be grabbed from storage, getting back to cultivation and being prepared for injection within a few weeks. This allows patients to benefit from using younger cells while avoiding having to undergo a second skin biopsy for the next injection.

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Swiss Medica Clinic in Serbia

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Skin regenerative treatment with AFT: personalized skin rejuvenation

In summary, autologous treatment is a skin rejuvenation procedure based on your own cells that is significantly superior to conventional techniques such as mesotherapy and PRP, and provides long-term results without the use of third-party materials and frequent follow-up visits to specialists, as required by Botox and hyaluronic acid injections. It is a personalized, natural and highly effective treatment that is considered by dermatologists and aging experts to be the most effective skin rejuvenation treatment available today. Its effect lasts for many years after one injection.

Fibroblasts play a key role in the creation of the dermal matrix and produce the main components of the skin. These cells are responsible for the structure, firmness, elasticity and hydration of the skin. Fibroblasts synthesize collagen, which provides the elasticity of the skin. Wrinkles characteristic of aging are primarily associated with collagen degradation, which is due, among other things, to a decrease in the number of fibroblasts. Fibroblasts also produce another important protein, elastin, which is responsible for skin elasticity. With age, elastin levels also decrease due to a decrease in the number of fibroblasts. An additional sign of skin aging is an increase in skin dryness, caused in particular by a decrease in the production of hyaluronic acid. AFT treatment can increase natural hyaluronic acid production for years, which helps fill in wrinkles and give skin a fresh, youthful appearance without disrupting its natural structure.

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Medeor Hospital in Dubai

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Skin regenerative treatment with AFT: effective remedy against wrinkles and scars

Facial skin often becomes a sign of time, characterized by the appearance of wrinkles and loss of elasticity. To most effectively counteract the signs of aging, experts are constantly improving methods of skin rejuvenation using regenerative treatment with AFT.

Wrinkles can appear on various areas of the face, such as the area above the upper lip, the corners of the eyes, the forehead and between the eyebrows. These changes are largely due to the loss of important skin components such as collagen, elastin and hyaluronic acid.

This process is also responsible for the formation of scars that occur after acne appears. Various fillers such as collagen and hyaluronic acid are widely used to correct these skin defects.

Although these methods are usually quite effective, they provide a temporary improvement in the appearance of the skin for only a few months, without completely solving the problem of its rejuvenation.

Natural treatment without the risk of an immune response

To prevent inflammatory reactions and allergic responses, the fibroblasts used in the procedure are autologous – they are extracted from the patient’s own tissue. This almost completely eliminates the possibility of immune rejection. A similar approach is used in the treatment of PRP, which explains the wide popularity and safety of this method. Unlike PRP, Autologous Fibroblast Therapy introduces skin fibroblasts, making them more suitable for working effectively in the body.

Expected results

Unlike filler injections, which bring quick but temporary changes, own AFT cells treatment  provides gradual but lasting improvement. Fibroblasts stimulate the production of collagen, elastin and hyaluronic acid in the injection area, which makes the skin tighter, firmer and restores its elasticity. The first results are usually noticeable within a few weeks, and they continue to improve over time, lasting long-term. As a result, the skin looks fresher and younger, wrinkles are smoothed out, elasticity increases, and the overall condition of the skin improves.

Clinically approved treatment

Dermatology and autologous fibroblast treatment has been carried out since 1995, and the results of clinical studies conducted on more than 2000 patients confirmed its effectiveness and safety. This is what led to the approval of the procedure in the United States.

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